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Thursday, September 6, 2012
Obama Being Pressed to Respond on Climate
A large group of Democratic donors is threatening to withhold money from President Obama?s reelection campaign unless he breaks his silence on climate change and responds directly to GOP presidential candidate Mitt Romney?s denigration of the issue at the Republican National Convention last week.
The donors want Obama to reject the advice of his campaign operatives and affirm his support for addressing climate change in his acceptance speech at the Democratic National Convention on Thursday night, said Betsy Taylor, a Democratic strategist and president of Breakthrough Strategies & Solutions.
?We?ve been working on behalf of a network of about 100 political donors who maxed out to the Obama campaign in 2008, and only about 25 percent have maxed out this election cycle,? Taylor said. ?The whole focus has been on elevating the climate issue. We do feel that it?s imperative that the president respond to Mitt Romney?s mocking and that he do so forcefully with a clear statement.?
In his acceptance speech at the Republican convention last week, Romney drew cheers from the delegates when he ridiculed Obama?s stance on climate change. ?President Obama promised to begin to slow the rise of the oceans and to heal the planet,? Romney said. ?My promise is to help you and your family.?
Obama has been largely mum on the issue of climate change in 2012 after promising to aggressively tackle the problem in his 2008 campaign. This year, in an election focused on the economy, Republicans have attacked any efforts to address climate change as ?job-killing regulations? and the White House has been reluctant to respond, despite recent polls showing most voters support action on climate change.
Taylor criticized the Obama campaign?s strategy on the issue. ?I think the president is getting very bad counsel,? she said. ?The people surrounding the president are giving him old advice. It?s not taking into account the new polling that shows people are considering a drought worse than anything we?ve seen in 50 years, wildfires raging through the Midwest?this isn?t speculative, this is science.
?His failure to talk about climate change?the silence is staggering in the wake of this summer?s extreme weather,? Taylor said. ?If he fails to stand up in the face of the mocking of the Republican convention, he will not get the kind of support he needs from independents, young people, and his donors.?
A poll conducted in 10 swing states last month by Yale University found that 55 percent of voters will consider candidates? views on global warming when deciding how to vote, and that 88 percent support U.S. action on climate change even if it has economic costs.
The Yale survey also found that 84 percent of Democrats, 77 percent of independent voters, and 67 percent of Republicans support regulating carbon dioxide as a pollutant. The poll concluded that being ?pro-climate? wins votes among Democrats and independents, and has little negative impact with Republican voters.
Other polls this year also have found that most Americans believe global temperatures are rising and weather patterns have become more unstable in recent years. An April Gallup poll found majority support for stricter pollution standards, government clean-energy efforts, and controls on greenhouse-gas emissions.
?Based on what I?ve seen of the polls, and of the campaigns, I?m perplexed,? said Edward Maibach, a co-author of the Yale study. ?Climate change does not appear to be the radioactive issue that politicians often believe it is. It?s very much in the president?s interest to take a pro-climate stance, because it will win him votes.... For Republicans, that stance will alienate some in their own party, but they?ll win as many independent voters, so it?s a wash.?
Maibach said that Romney?s remarks on climate change may come back to haunt him. ?Mocking climate change or taking an anti-climate stance plays to the extreme conservative base,? he said. ?If the point is to rally the base, then belittling the notion that the climate is changing is effective. But it has a cost. It will likely lose you votes that you need to get elected from independents in the middle.?
Both campaigns and their surrogates declined to answer questions about the polls on climate change. But Obama?s campaign advisers said the script of his Thursday speech remains a work in progress, and it?s an open question as to whether climate change will be mentioned.
There are signs that Obama is starting to elevate the issue of climate change. In three speeches last week, he highlighted his administration?s new fuel-economy standards, which require automakers to build cars with an average fuel economy of 54.5 miles per gallon by 2025. ?That will reduce greenhouse-gas emissions by a level roughly equivalent to a year?s worth of emissions from all the cars in the world,? he told audiences in Iowa, Colorado, and Virginia?each time to applause.
Strategists from both parties say that the reason the GOP has veered so hard to the right on energy and climate issues is the influx of new spending by outside groups and super PACs, many of which have ties to fossil-fuel companies that oppose climate regulations. One of the most influential groups is Americans for Prosperity, backed by energy conglomerate Koch Industries.
The president of Americans for Prosperity, Tim Phillips, spoke with National Journal by phone from a bus in North Carolina, where the group is on a tour highlighting ?Obama?s Failing Agenda.?
?There?s no question? that Romney?s remarks will resonate positively with voters, Phillips said. ?It?s no wonder the president is silent on this. They know what we know. It?s not something the American public supports.?
It?s expected that both candidates will have to answer questions on climate change during the presidential debates, the first of which is scheduled for Oct. 3 in Denver. Some scientists say that Colorado, which has been hit by swarms of pine beetles and devastating wildfires this summer, has seen?one of the earliest and most visible impacts of climate change in the U.S.
?The issue could be extra-salient in Colorado and at the Denver debate, where related issues have been hot (pun intended),? wrote Colorado-based Republican strategist Mark McKinnon in an e-mail to National Journal.
Source: http://news.yahoo.com/obama-being-pressed-respond-climate-193544755--politics.html
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Wednesday, September 5, 2012
Scientists design molecule that reverses some fragile X syndrome defects
Wednesday, September 5, 2012
Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.
The study, published online ahead of print in the journal ACS Chemical Biology September 4, 2012, focuses on tremor ataxia syndrome, which usually affects men over the age of 50 and results in Parkinson's like-symptoms?trembling, balance problems, muscle rigidity, as well as some neurological difficulties, including short-term memory loss and severe mood swings.
With fragile X syndrome, tremor ataxia syndrome, and related diseases, the root of the problem is a structural motif known as an "expanded triplet repeat"?in which a series of three nucleotides are repeated more times than normal in the genetic code of affected individuals. This defect, located in the fragile X mental retardation 1 (FMR1) gene, causes serious problems with the processing of RNA.
"While there is an abundance of potential RNA drug targets in disease, no one has any idea how to identify or design small molecules to target these RNAs," said Mathew Disney, a Scripps Research associate professor who led the study. "We have designed a compound capable of targeting the right RNA and reversing the defects that cause fragile X-associated tremor ataxia."
Preventing Havoc
In tremor ataxia syndrome, the expanded triplet repeat leads to the expression of aberrant proteins that wreak widespread havoc. The repeats actually force the normal proteins that regulate RNA splicing?necessary for production of the right kind of proteins?into hiding.
The compound designed by Disney and his colleagues not only improves the RNA splicing process, but also minimizes the ability of repeats to wreak havoc on a cell.
"It stops the repeat-associated defects in cell culture," Disney said, "and at fairly high concentrations, it completely reverses the defects. More importantly, the compound is non-toxic to the cells. It looks like a very good candidate for development, but we're still in the early stages of testing."
Overall, this study reinforces Disney's earlier findings showing it is possible to identify and develop small molecules that target these traditionally recalcitrant RNA defects. In March of this year, Disney published a study in the Journal of the American Chemical Society that described a small molecule that inhibited defects in myotonic dystrophy type 1 RNA in both cellular and animal models of disease.
"We've gotten very good at targeting RNA with small molecules, something a lot of people said couldn't be done," Disney pointed out. "Our approach is evolving into a general method that can be used to target any disease that is associated with an RNA, including, perhaps, fragile X syndrome itself."
The new compound also works as a probe to better understand how these repeats cause fragile X syndrome and how they contribute to tremor ataxia, Disney added.
###
Scripps Research Institute: http://www.scripps.edu
Thanks to Scripps Research Institute for this article.
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Barker 'fine' with exclusion from 'Price' special
FILE - In this June 6, 2007 file photo shows game show host Bob Barker gesturing during the taping of his final episode of "The Price Is Right" in Los Angeles. The 40th anniversary special of the popular daytime game show aired Tuesday, Sept. 4, 2012 on CBS. (AP Photo/Damian Dovarganes, file)
FILE - In this June 6, 2007 file photo shows game show host Bob Barker gesturing during the taping of his final episode of "The Price Is Right" in Los Angeles. The 40th anniversary special of the popular daytime game show aired Tuesday, Sept. 4, 2012 on CBS. (AP Photo/Damian Dovarganes, file)
FILE - In this June 6, 2007 file photo shows game show host Bob Barker gesturing during the taping of his final episode of "The Price Is Right" in Los Angeles. The 40th anniversary special of the popular daytime game show aired Tuesday, Sept. 4, 2012 on CBS. (AP Photo/Damian Dovarganes, file)
LOS ANGELES (AP) ? Bob Barker hosted "The Price Is Right" for 35 years, but he wasn't invited to participate in the game show's 40th anniversary special.
The 88-year-old TV personality says the show's producers "chose to ignore me, which is fine."
"They haven't even offered me a DVD," Barker said in an interview Tuesday. Show producers had no comment.
The 40th anniversary special episode aired Tuesday morning and featured returning contestants from the past 40 years. Barker is shown in several clips but was not invited to appear on the program or attend the taping.
Barker announced his retirement in 2006 and hosted his final show in 2007. He was replaced by Drew Carey.
Barker made a special appearance on the show ? which is taped at CBS' Bob Barker Theater ? in 2009.
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Borisizaguirre: @paurubio en Italia? Que maravilla!! Boys will be boys even more in Rome!!! Love, boris
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Tuesday, September 4, 2012
Pearl Jam closes 2-day Made In America festival
Pearl Jam performs at the "Made In America" music festival on Sunday Sept. 2, 2012, in Philadelphia. (Photo by Drew Gurian/Invision/AP)
Pearl Jam performs at the "Made In America" music festival on Sunday Sept. 2, 2012, in Philadelphia. (Photo by Drew Gurian/Invision/AP)
Pearl Jam performs at the "Made In America" music festival on Sunday Sept. 2, 2012, in Philadelphia. (Photo by Drew Gurian/Invision/AP)
Drake performs at the "Made In America" music festival on Sunday, Sept. 2, 2012, in Philadelphia. (Photo by Charles Sykes/Invision/AP)
Drake performs at the "Made In America" music festival on Sunday, Sept. 2, 2012, in Philadelphia. (Photo by Charles Sykes/Invision/AP)
Drake performs at the "Made In America" music festival on Sunday, Sept. 2, 2012, in Philadelphia. (Photo by Charles Sykes/Invision/AP)
PHILADELPHIA (AP) ? If closing out a two-day festival with an intense two-hour set wasn't enough for Pearl Jam, then bringing out the man who organized it sealed the deal.
Jay-Z joined the group for its second-to-last encore Sunday with a rocking version of his signature hit "99 Problems."
While Jay closed out the first night of the Budweiser Made in America Festival, he handed the torch to the Seattle-based band grunge rockers and they did not disappoint.
Their 25-song set saw tens of thousands of fans jumping, dancing, and singing on the muggy September night to the band's well-known tracks like "Alive," ''Better Man," and "Jeremy."
For the song "Unemployable," Vedder told the crowd it was about a hard-working family man who did all the right things in life, but became the victim of job cuts. He said sometimes the so-called job creators are creating jobs outside the United States.
"I want to see more things made in America" Vedder said, to thunderous applause.
Vedder also urged people to get out and vote, before a rousing cover of the Clash's "Know Your Rights." Fittingly, the band ended the show with Neil Young's "Rockin' in the Free World."
But Pearl Jam wasn't the only big story, as earlier in the day Run DMC performed for the first time in over a decade.
Taking the stage under a video banner that read "Jam Master Jay Forever," the Queens, N.Y., natives were well received by fans who danced to the music and sang along, some better than others. Beyonc? and Jay-Z strolled through the crowd flanked by security.
Their 40-minute set included "It's Tricky" to a sea of flailing arms, and "It's Like That." Run even put on a pair of namesake sneakers for "My Adidas."
But perhaps the most poignant moment came when Run talked about the breakup following the death of Jam Master Jay.
"After his assassination ... we put a silence on the group," Run said.
Jam Master Jay, Run DMC's longtime DJ, was fatally shot in 2002. The case was never solved.
Run introduced Jay's sons T.J. Mizell and Jam Master J'Son who honored their father with "some beats." Afterward, Run said, "Jay, I know you're looking down from Heaven."
Other notable performances included Frank Ocean and his Odd Future gang, performing an alternative rap set. Drake played the main stage, aptly named the Rocky stage since it sat at the bottom of the steps where the classic "Rocky" movie scene was filmed.
The Canadian rapper, who apparently never met an expletive he didn't like, energized the crowd with a 45-minute set. And if there was a roof over '70s punk band X, it would have blown off.
While the threat of rain loomed for most of the day, the only real precipitation was the Budweiser-soaked earth in front of the stages. The performances all ran on time and the sound was pretty amazing for an outdoor venue. Even the crowd was well behaved with enough space for them to roam.
In one funny moment, a large gentleman cut the bathroom line in the VIP area and opened the door to a portable unit for a brief inspection. Holding back the crowd, he said: "Right here, Miss B."
Beyonc? took a look, nodded her head, and the entourage continued on. Later, she walked with husband Jay-Z and Rita Ora to catch Drake's performance. It was that kind of night.
___
Online: http://www.madeinamericafest.com
___
John Carucci covers entertainment for The Associated Press. Follow him at http://www.twitter.com/jcarucci_ap .
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Restaurants Start Charging More For Peak Dinner Times - Business ...
The restaurant industry is notoriously low-margin. The cost of doing business is the same whether the restaurant is empty or full.?
Now the industry is hitting back and looking at ways to charge more for dinner at peak times, Stephanie Clifford at the New York Times reports.
She writes:
"The restaurants? premise is that a dinner at an 8 p.m. on Saturday should simply cost more than one at 5:30 on a Monday. ?Restaurants are catching up,? said Sheryl E. Kimes, professor of operations management at Cornell?s school of hotel administration. "They are betting that consumers, used to paying extra for holiday-weekend flights, V.I.P. seats at the theater or umbrellas on the street after the first raindrop hits, will also pay more for their Friday-night dinners out."
Some restaurants are already experimenting with different prices based on time. Fancy Manhattan restaurant Le Cirque uses an app called Savored, which offers cheaper meals based on reservation time. Another app called Leloca allows restaurants to contact users with promotions if a big party fails.
The Times reports that research from Cornell suggests that consumers might be comfortable with the idea of paying more for peak dinner times:?
"People were O.K. with different prices by time of day and day of week, but what made that even more pronounced was the way you framed it,? (Professor Kimes at Cornell) said. ?If you said it?s 20 percent cheaper to come during the week than on the weekend, people thought that was more acceptable than if you said it?s 20 percent more expensive on the weekend.?
DON'T MISS: The Average College Student Is Spending A Record $907 On Dorm Decor >
Source: http://www.businessinsider.com/restaurants-start-charging-more-for-peak-dinner-times-2012-9
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